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Messenger RNA surveillance neutralizing natural nonsense
Messenger RNA surveillance: neutralizing natural nonsense.
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Messenger RNA transcripts that contain premature stop codons are degraded by a process termed nonsense-mediated mRNA decay (NMD). Although previously thought of as a pathway that rids the cell of non-functional mRNAs arising from mutations and processing errors, new research suggests a more general and evolutionarily important role for NMD in the control of gene expression.
Weischenfeldt J, Lykke-Andersen J, Porse B
Current biology : CB
2005-07-26 00:00
15
14
R559-62
Animals,Caenorhabditis elegans,Codon, Nonsense,Gene Expression Regulation,Mice,Models, Biological,Pseudogenes,RNA Helicases,RNA Stability,RNA, Small Nucleolar,Codon, Nonsense,RNA, Small Nucleolar,RNA Helicases
Section of Gene Therapy Research, Copenhagen University Hospital, Juliane Mariesvej 20 section 9322, DK-2100 Copenhagen, Denmark Joachimweischenfeldtrhhospdk
Curr. Biol.
0960-9822
10.1016/j.cub.2005.07.002
S0960-9822(05)00710-4
810
True
16051166
