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Soy diet worsens heart disease in mice
Soy diet worsens heart disease in mice.
24
We report that dietary modification from a soy-based diet to a casein-based diet radically improves disease indicators and cardiac function in a transgenic mouse model of hypertrophic cardiomyopathy. On a soy diet, males with a mutation in the alpha-myosin heavy chain gene progress to dilation and heart failure. However, males fed a casein diet no longer deteriorate to severe, dilated cardiomyopathy. Remarkably, their LV size and contractile function are preserved. Further, this diet prevents a number of pathologic indicators in males, including fibrosis, induction of beta-myosin heavy chain, inactivation of glycogen synthase kinase 3beta (GSK3beta), and caspase-3 activation.
Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA
The Journal of clinical investigation
2006-01-01 00:00
116
1
209-16
Animals,Cardiomyopathy, Dilated,Disease Models, Animal,Disease Progression,Female,Heart,Heart Diseases,Male,Mice,Mutation,Myosin Heavy Chains,Organ Size,Sex Characteristics,Soybean Proteins,Myosin Heavy Chains,Soybean Proteins
Department of Medicine, Division of Cardiology, University of Colorado Health Sciences Center, Denver, Colorado, USA
J. Clin. Invest.
NHLBI 1F32HL67543, NHLBI 2R01HL050560, NHLBI 5F32HL070509
0021-9738
10.1172/JCI24676
787
True
16395406
