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Molecular events underlying pregnancy-induced cardiomyopathy
Molecular events underlying pregnancy-induced cardiomyopathy.
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The etiology of cardiomyopathy in pregnant women remains unclear. In this issue, Hilfiker-Kleiner et al. (2007) report that a reduction in STAT3 and a concomitant increase in cathepsin D may be a cause of this disease. Cathepsin D generates an antiangiogenic cleavage product of the hormone prolactin. The authors show that an inhibitor of prolactin secretion may be useful in treating this disease.
Leinwand LA
Cell
2007-02-09 00:00
128
3
437-8
Animals,Bromocriptine,Cardiomyopathies,Cathepsin D,Disease Models, Animal,Female,Humans,Pregnancy,Pregnancy Complications, Cardiovascular,Prolactin,Puerperal Disorders,STAT3 Transcription Factor,STAT3 Transcription Factor,Bromocriptine,Prolactin,Cathepsin D
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA leinwandcoloradoedu
Cell
0092-8674
10.1016/j.cell.2007.01.020
S0092-8674(07)00118-3
751
True
17289564
