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Mechanisms of the pathogenesis of tropon ... ial hypertrophic cardiomyopathy
Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopathy.
24
Mutations in cardiac troponin T (cTnT) cause hypertrophic cardiomyopathy characterized by comparatively little cardiac hypertrophy, but a high incidence of sudden cardiac death. Transgenic mice modeling this disease have smaller cardiomyocytes, leading to smaller hearts. However, different mutations in cTnT have distinct phenotypes with respect to fibrosis, induction of molecular markers, and systolic function. Such models ideally allow for testing of the role of individual phenotypes in the pathways leading to cardiomyopathy, as well as identification of factors such as exercise that can affect the disease.
Maass AH, Leinwand LA
Trends in cardiovascular medicine
2003-08-01 00:00
13
6
232-7
Animals,Cardiomyopathy, Hypertrophic, Familial,Disease Models, Animal,Exercise,Humans,Mutation,Signal Transduction,Troponin T,Troponin T
Department of Medicine, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany
Trends Cardiovasc. Med.
NHLBI HL 50565
1050-1738
S1050173803001002
745
True
12922019
