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Genetic variability in forced and volunt ... e in seven inbred mouse strains
Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains.
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The goal of this study was to characterize the genetic contribution to both forced and voluntary exercise performance and to determine whether performance in these two paradigms is controlled by similar genetic influences. There were marked strain differences in treadmill exercise performance, with Swiss Webster (SW) and FVB/NJ mice showing elevated performance and C57BL/6J animals showing decreased performance compared with all other strains. There was no apparent relationship between treadmill performance and voluntary wheel performance, with the exception of SW mice, which demonstrated high performances on both the treadmill and the voluntary wheel. Numerous properties were measured to attempt to understand the basis for these differences in exercise performance. DBA/1J and SW mice exhibited significantly greater cardiac contractility than all other analyzed strains. Conversely, BALB/cByJ mice exhibited significantly reduced cardiac contractility compared with all other strains. Expression of molecular indicators of hypertrophy (atrial natriuretic factor and beta-myosin heavy chain) was significantly elevated in DBA/2J myocardium compared with all other analyzed strains.
Lerman I, Harrison BC, Freeman K, Hewett TE, Allen DL, Robbins J, Leinwand LA
Journal of applied physiology (Bethesda, Md. : 1985)
2002-06-01 00:00
92
6
2245-55
Animals,Echocardiography,Gene Expression,Heart,Hemodynamic Processes,Mice,Mice, Inbred Strains,Motor Activity,Muscle, Skeletal,Organ Size,Physical Endurance,Variation (Genetics),Volition
Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, 80309, USA LeslieLeinwandColoradoedu
J. Appl. Physiol.
NIGMS GM-29090
8750-7587
10.1152/japplphysiol.01045.2001
724
True
12015333
