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Inversion, duplication, and changes in g ... h human chromosome 18 evolution
Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution.
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Human chromosome 18 differs from its homologues in the great apes by a pericentric inversion. We have identified a chimpanzee bacterial artificial chromosome that spans a region where a break is likely to have occurred in a human progenitor and have characterized the corresponding regions in both chimpanzees and humans. Interspecies sequence comparisons indicate that the ancestral break occurred between the genes ROCK1 and USP14. In humans, the inversion places ROCK1 near centromeric heterochromatin and USP14 adjacent to highly repetitive subtelomeric repeats. In addition, we provide evidence for a human segmental duplication that may have provided a mechanism for the inversion.
Dennehey BK, Gutches DG, McConkey EH, Krauter KS
Genomics
2004-03-01 00:00
83
3
493-501
Animals,Base Sequence,Centromere,Chromosome Mapping,Chromosomes, Artificial, Bacterial,Chromosomes, Human, Pair 18,Evolution, Molecular,Gene Duplication,Gene Library,Humans,Inversion, Chromosome,Mice,Molecular Sequence Data,Pan paniscus,Rats,Synteny
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA
Genomics
NIDA DA12845
0888-7543
10.1016/j.ygeno.2003.08.017
S0888754303002702
657
True
14962675
