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A genome-wide search for quantitative tr ... ce vulnerability in adolescence
A genome-wide search for quantitative trait loci influencing substance dependence vulnerability in adolescence.
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This study describes results from a genome-wide search for quantitative trait loci (QTL) influencing substance dependence vulnerability in adolescence. We utilized regression-based multipoint (and single-point) QTL mapping procedures designed for selected sibpair samples. Selected sibling pairs included 250 proband-sibling pairs from 192 families. Clinical probands (13-19 years of age) were drawn from consecutive admissions to substance abuse treatment facilities in the Denver metropolitan area; siblings of probands ranged in age from 12 to 25 years. In addition to the selected sample, a community-based sample of 3676 adolescents and young adults were utilized to define a clinically-significant, heritable, age- and sex-normed index of substance dependence vulnerability-a priori and independent of our linkage results. Siblings and their parents were genotyped for 374 STR micro-satellite markers distributed across the 22 autosomes (average inter-marker distance=9.2 cM). Non-parametric single-point linkage results indicated 17 markers on 11 chromosomes with nominally significant tests of linkage; six markers with LOD scores greater than 1.0 and one marker (D3S1614) with a LOD score of 2.2. Multipoint mapping corroborated two locations and provided preliminary evidence for linkage to regions on chromosome 3q24-25 (near markers D3S1279 and D3S1614) and chromosome 9q34 (near markers D9S1826 and D9S1838).
Stallings MC, Corley RP, Hewitt JK, Krauter KS, Lessem JM, Mikulich SK, Rhee SH, Smolen A, Young SE, Crowley TJ
Drug and alcohol dependence
2003-06-05 00:00
70
3
295-307
Adolescent,Adult,Child,Chromosome Mapping,Chromosomes, Human, Pair 3,Chromosomes, Human, Pair 9,Colorado,Female,Genome, Human,Genotype,Humans,Linkage (Genetics),Lod Score,Male,Microsatellite Repeats,Quantitative Trait Loci,Substance-Related Disorders
Institute for Behavioral Genetics, University of Colorado, Campus Box 447, Boulder, CO 80309-0447, USA michaelstallingscoloradoedu
NIDA DA 05131, NIDA DA 11015, NIDA DA 12845
0376-8716
S0376871603000310
646
True
12757967
