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Inhibition of poliovirus RNA synthesis by brefeldin A
Inhibition of poliovirus RNA synthesis by brefeldin A.
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Brefeldin A (BFA), a fungal metabolite that blocks transport of newly synthesized proteins from the endoplasmic reticulum, was found to inhibit poliovirus replication 10(5)- to 10(6)-fold. BFA does not inhibit entry of poliovirus into the cell or translation of viral RNA. Poliovirus RNA synthesis, however, is completely inhibited by BFA. A specific class of membranous vesicles, with which the poliovirus replication complex is physically associated, is known to proliferate in poliovirus-infected cells. BFA may inhibit poliovirus replication by preventing the formation of these vesicles.
Maynell LA, Kirkegaard K, Klymkowsky MW
Journal of virology
1992-04-01 00:00
66
4
1985-94
Adenoviridae,Antiviral Agents,Brefeldin A,Cyclopentanes,Fluorescent Antibody Technique,Hela Cells,Humans,Kinetics,Lipids,Poliovirus,Protein Biosynthesis,RNA, Viral,Virus Replication,Antiviral Agents,Cyclopentanes,Lipids,RNA, Viral,Brefeldin A
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347
J. Virol.
NIAID AI-25166
0022-538X
622
True
1312615
