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Cortical excitatory neurons and glia, bu ... in the Emx1-expressing lineage
Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage.
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By homologous recombination of an internal ribosome entry site and Cre recombinase coding region into the 3'-untranslated region of the mouse Emx1 gene, we have generated a strain of mice, Emx1(IRES)cre, that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1. When mated to reporter strains, these mice are a sensitive means to fate-map the Emx1-expressing cells of the developing forebrain. Our results demonstrate that radial glia, Cajal-Retzius cells, glutamatergic neurons, astrocytes, and oligodendrocytes of most pallial structures originate from an Emx1-expressing lineage. On the other hand, most of the pallial GABAergic neurons arise outside the Emx1-expressing lineage. Structures that are located near the basal ganglia (e.g., the amygdala and endopiriform nuclei) are not uniformly derived from Emx1-expressing cells.
Gorski JA, Talley T, Qiu M, Puelles L, Rubenstein JL, Jones KR
The Journal of neuroscience : the official journal of the Society for Neuroscience
2002-08-01 00:00
22
15
6309-14
3' Untranslated Regions,Amygdala,Animals,Basal Ganglia,Cell Lineage,Cerebral Cortex,Gene Targeting,Genes, Reporter,Homeodomain Proteins,Integrases,Interneurons,Mice,Mice, Mutant Strains,Models, Animal,Neuroglia,Neurons,Recombination, Genetic,Stem Cells,Telencephalon,Transcription Factors,Viral Proteins,gamma-Aminobutyric Acid,3' Untranslated Regions,Homeodomain Proteins,Transcription Factors,Viral Proteins,empty spiracles homeobox proteins,gamma-Aminobutyric Acid,Cre recombinase,Integrases
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
J. Neurosci.
1529-2401
20026564
22/15/6309
590
True
12151506
