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The C elegans evl-20 gene is a homolog o ... g cytokinesis and morphogenesis
The C. elegans evl-20 gene is a homolog of the small GTPase ARL2 and regulates cytoskeleton dynamics during cytokinesis and morphogenesis.
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The in vivo functions of ARF-like members of the Ras superfamily of GTPases are relatively unexplored. Here we describe the analysis of C. elegans evl-20 gene that encodes a functional homolog of human ARL2. Elimination of evl-20 function results in abnormal vulval, gonad, and male tail development and disrupts embryonic proliferation, hypodermal enclosure, and elongation. Loss of evl-20 function causes specific defects in the microtubule cytoskeleton, which is the likely molecular basis for the observed defects. EVL-20 is closely associated with both the cell cortex and astral microtubules, suggesting that it may directly interact with microtubule structures at those locations. Our data indicate that EVL-20 functions in the cytoplasm and at the plasma membrane to regulate cytoskeletal dynamics during cytokinesis and morphogenesis.
Antoshechkin I, Han M
Developmental cell
2002-05-01 00:00
2
5
579-91
Amino Acid Sequence,Animals,Base Sequence,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cell Division,Cytoskeleton,DNA, Helminth,Female,GTP-Binding Proteins,Gene Expression Regulation, Developmental,Genes, Helminth,Gonads,Humans,Male,Molecular Sequence Data,Mutation,Phenotype,Sequence Homology, Amino Acid,Tail,Vulva,Caenorhabditis elegans Proteins,DNA, Helminth,evl-20 protein, C elegans,ARL2 protein, human,GTP-Binding Proteins
Department of Molecular, Cellular, and Developmental Biology, Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA
Dev. Cell
NIGMS GM 47869, NCI P30 CA 46934
1534-5807
S1534580702001466
518
True
12015966
