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Ras proteins in developmental pattern fo ... habditis elegans and Drosophila
Ras proteins in developmental pattern formation in Caenorhabditis elegans and Drosophila.
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Recent studies of genetically isolated mutants in Caenorhabditis elegans and Drosophila have revealed ras functions in developmental pattern formation. The ras proteins act as genetic switches to determine cell fates between two alternative choices during C elegans vulval development (vulval versus hypodermal cells) and during Drosophila eye development (R7 versus cone cell). In both cases, ras proteins act downstream of a receptor tyrosine kinase in a signal transduction pathway that mediates cell-cell interactions. These genetic systems may allow the further elucidation of ras-mediated developmental regulatory pathways.
Han M
Seminars in cancer biology
1992-08-01 00:00
3
4
219-28
Animals,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Drosophila,Drosophila Proteins,Eye,Eye Proteins,Female,Gene Expression Regulation,Genes,Genes, ras,Helminth Proteins,Membrane Glycoproteins,Receptor Protein-Tyrosine Kinases,Signal Transduction,Vulva,ras Proteins,Caenorhabditis elegans Proteins,Drosophila Proteins,Eye Proteins,Helminth Proteins,Membrane Glycoproteins,let-60 protein, C elegans,Receptor Protein-Tyrosine Kinases,sev protein, Drosophila,ras Proteins
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309
Semin. Cancer Biol.
1044-579X
507
True
1421166
