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Genetic redundancy masks diverse functio ... EN during C elegans development
Genetic redundancy masks diverse functions of the tumor suppressor gene PTEN during C. elegans development.
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Genetic redundancy is associated with a large percentage of genes. We investigated PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor gene functions that eluded single mutant analyses, using a Caenorhabditis elegans genome-wide screen. We show that at least 27 genes collaborate with the worm PTEN homolog daf-18 for various functions previously concealed by genetic redundancy, including embryogenesis, cuticle turnover, egg laying, and oocyte maturation. In one example, daf-18 appears to constitute a cell-autonomous germline signal that converges with a somatic gonad signal mediated by ceh-18 at a kinase inhibition. We provide evidence that daf-18 elicits some functions independent of the downstream gene daf-16.
Suzuki Y, Han M
Genes & development
2006-02-15 00:00
20
4
423-8
Animals,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cell Cycle Proteins,In Situ Hybridization,Mitogen-Activated Protein Kinases,Oocytes,Ovulation,Phenotype,Polymerase Chain Reaction,RNA Interference,Signal Transduction,Caenorhabditis elegans Proteins,Cell Cycle Proteins,DAF-18 protein, C elegans,Mitogen-Activated Protein Kinases
Howard Hughes Medical Institute and Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA
Genes Dev.
0890-9369
10.1101/gad.1378906
20/4/423
486
True
16481471
