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Control and integration of cell signalin ... ng C elegans vulval development
Control and integration of cell signaling pathways during C. elegans vulval development.
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Vulval development in the Caenorhabditis elegans hermaphrodite represents a simple, genetically tractable system for studying how cell signaling events control cell fate decisions. Current models suggest that proper specification of vulval cell fates relies on the integration of multiple signaling systems, including one that involves a receptor tyrosine kinase (RTK)-->Ras-->mitogen activated protein kinase (MAPK) cascade and one that involves a LIN-12/Notch family receptor. In this review, we first discuss how genetic strategies are being used to identify and analyze components that control vulval cell fate decisions. We then describe the different signaling systems that have been elucidated and how they relate to one another. Finally, we highlight several recently characterized genes that encode positive regulators, negative regulators or potential targets of the RTK-->Ras-->MAPK cascade involved in vulval induction.
Sundaram M, Han M
BioEssays : news and reviews in molecular, cellular and developmental biology
1996-06-01 00:00
18
6
473-80
Animals,Ca(2+)-Calmodulin Dependent Protein Kinase,Caenorhabditis elegans,Female,Male,Membrane Proteins,Receptor Protein-Tyrosine Kinases,Receptors, Notch,Signal Transduction,Vulva,ras Proteins,Membrane Proteins,Receptors, Notch,Receptor Protein-Tyrosine Kinases,Ca(2+)-Calmodulin Dependent Protein Kinase,ras Proteins
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-347, USA mhanstripecoloradoedu
Bioessays
NIGMS R01 GM47869
0265-9247
10.1002/bies.950180609
477
True
8787535
