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C elegans lin-45 raf gene participates i ... imulated vulval differentiation
C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation.
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Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.
Han M, Golden A, Han Y, Sternberg PW
Nature
1993-05-13 00:00
363
6425
133-40
Amino Acid Sequence,Animals,Base Sequence,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Cell Differentiation,Cloning, Molecular,DNA,Female,Helminth Proteins,Humans,Male,Molecular Sequence Data,Mutation,Protein-Serine-Threonine Kinases,Proto-Oncogene Proteins,Proto-Oncogene Proteins c-raf,Sequence Homology, Amino Acid,Vulva,ras Proteins,Caenorhabditis elegans Proteins,Helminth Proteins,Proto-Oncogene Proteins,let-60 protein, C elegans,DNA,Protein-Serine-Threonine Kinases,Proto-Oncogene Proteins c-raf,ras Proteins
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder 80309-0347
Nature
0028-0836
10.1038/363133a0
471
True
8483497
