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A PP2A regulatory subunit positively reg ... bditis elegans vulval induction
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction.
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We describe evidence that a regulatory B subunit of protein phosphatase 2A (PP2A) positively regulates an RTK-Ras-MAP kinase signaling cascade during Caenorhabditis elegans vulval induction. Although reduction of sur-6 PP2A-B function causes few vulval induction defects in an otherwise wild-type background, sur-6 PP2A-B mutations suppress the Multivulva phenotype of an activated ras mutation and enhance the Vulvaless phenotype of mutations in lin-45 raf, sur-8, or mpk-1. Double mutant analysis suggests that sur-6 PP2A-B acts downstream or in parallel to ras, but likely upstream of raf, and functions with ksr-1 in a common pathway to positively regulate Ras signaling.
Sieburth DS, Sundaram M, Howard RM, Han M
Genes & development
1999-10-01 00:00
13
19
2562-9
Adaptor Proteins, Signal Transducing,Amino Acid Sequence,Animals,Base Sequence,Caenorhabditis elegans,Caenorhabditis elegans Proteins,Carrier Proteins,DNA, Helminth,Embryonic Induction,Female,Helminth Proteins,Humans,Molecular Sequence Data,Phosphoprotein Phosphatase,Protein Kinases,Sequence Homology, Amino Acid,Signal Transduction,Vulva,ras Proteins,Adaptor Proteins, Signal Transducing,Caenorhabditis elegans Proteins,Carrier Proteins,DNA, Helminth,Helminth Proteins,SUR-8 protein, C elegans,KSR-1 protein kinase,Protein Kinases,Phosphoprotein Phosphatase,ras Proteins
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309-0347, USA
Genes Dev.
NIGMS GM47869
0890-9369
458
True
10521400
