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Lets get specific the relationship between specificity and affinity
Let's get specific: the relationship between specificity and affinity.
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The factors that lead to high-affinity binding are a good fit between the surfaces of the two molecules in their ground state and charge complementarity. Exactly the same factors give high specificity for a target. We argue that selection for high-affinity binding automatically leads to highly specific binding. This principle can be used to simplify screening approaches aimed at generating useful drugs.
Eaton BE, Gold L, Zichi DA
Chemistry & biology
1995-10-01 00:00
2
10
633-8
Animals,Drug Design,Humans,Protein Binding,Receptors, Drug,Surface Properties,Receptors, Drug
NeXstar Pharmaceuticals, Inc, Boulder, CO 80301, USA
Chem. Biol.
1074-5521
1074-5521(95)90023-3
419
True
9383468
