Document Actions
Allosteric drugs thinking outside the active-site box
Allosteric drugs: thinking outside the active-site box.
49
Recently, a class of small molecules that thermally stabilize the tumor suppressor p53 was selected from a small-molecule library. This, and other recent work, demonstrates the feasibility of taking a lead from nature and selecting new classes of drugs that function by allosteric mechanisms.
DeDecker BS
Chemistry & biology
2000-05-01 00:00
7
5
R103-7
Allosteric Regulation,Binding Sites,Humans,Nitric Oxide Synthase,Nitric Oxide Synthase Type II,Peptide Library,Protein Engineering,Tumor Suppressor Protein p53,Peptide Library,Tumor Suppressor Protein p53,NOS2A protein, human,Nitric Oxide Synthase,Nitric Oxide Synthase Type II
Harvard Institute of Chemistry and Cell Biology, Boston, MA 02115-5731, USA briandedeckerhmsharvardedu
Chem. Biol.
1074-5521
S1074-5521(00)00115-0
343
True
10801477
