Document Actions
Telomerase and the maintenance of chromosome ends
Telomerase and the maintenance of chromosome ends.
68
The catalytic subunit of telomerase has recently been identified in diverse eukaryotes and shown to be a reverse transcriptase. Ectopic expression of this protein in normal human cells leads to lengthened telomeres and an extended in vitro life span. Other proteins that modulate telomerase activity in vivo are also being identified, including a functionally conserved family of proteins with Myb-like DNA-binding domains and proteins that are involved in DNA double-strand break repair.
Bryan TM, Cech TR
Current opinion in cell biology
1999-06-01 00:00
11
3
318-24
Animals,Humans,Telomerase,Telomere,Telomerase
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, Campus box 215, University of Colorado, Boulder, CO 80309-0215, USA tracybryancoloradoedu
Curr. Opin. Cell Biol.
0955-0674
10.1016/S0955-0674(99)80043-X
S0955-0674(99)80043-X
285
True
10395557
