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Atomic level architecture of group I introns revealed
Atomic level architecture of group I introns revealed.
68
Twenty-two years after their discovery as ribozymes, the self-splicing group I introns are finally disclosing their architecture at the atomic level. The crystal structures of three group I introns solved at moderately high resolution (3.1-3.8A) reveal a remarkably conserved catalytic core bound to the metal ions required for activity. The structure of the core is stabilized by an intron-specific set of long-range interactions that involves peripheral elements. Group I intron structures thus provide much awaited and extremely valuable snapshots of how these ribozymes coordinate substrate binding and catalysis.
Vicens Q, Cech TR
Trends in biochemical sciences
2006-01-01 00:00
31
1
41-51
Binding Sites,Conserved Sequence,DNA,DNA, Bacterial,Exons,Introns,Models, Molecular,Nucleic Acid Conformation,RNA,RNA, Catalytic,DNA, Bacterial,RNA, Catalytic,RNA,DNA
Howard Hughes Medical Institute and Department of Chemistry and Biochemistry, University of Colorado, UCB 215, Boulder, CO 80309-0215, USA
Trends Biochem. Sci.
0968-0004
10.1016/j.tibs.2005.11.008
S0968-0004(05)00340-3
150
True
16356725
