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mago nashi mediates the posterior follic ... ze axis formation in Drosophila
mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila.
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Establishment of the anteroposterior and dorsoventral axes in the Drosophila egg chamber requires reciprocal signaling between the germ line and soma. Upon activation of the Drosophila EGF receptor in the posterior follicle cells, these cells signal back to the oocyte, resulting in a reorganization of the oocyte cytoplasm and anterodorsal migration of the oocyte nucleus. We demonstrate that the gene mago nashi (mago) encodes an evolutionarily conserved protein that must be localized within the posterior pole plasm for germ-plasm assembly and Caenorhabditis elegans mago is a functional homologue of Drosophila mago. In the absence of mago+ function during oogenesis, the anteroposterior and dorsoventral coordinates of the oocyte are not specified and the germ plasm fails to assemble.
Newmark PA, Mohr SE, Gong L, Boswell RE
Development (Cambridge, England)
1997-08-01 00:00
124
16
3197-207
Amino Acid Sequence,Animals,Body Patterning,Caenorhabditis elegans,Cell Nucleus,Drosophila,Drosophila Proteins,Female,Genes, Insect,Homeodomain Proteins,Insect Proteins,Kinesin,Mice,Microtubules,Molecular Sequence Data,Nuclear Proteins,Oocytes,Oogenesis,Phenotype,RNA, Messenger,Recombinant Fusion Proteins,Sequence Homology, Amino Acid,Trans-Activators,Transforming Growth Factor alpha,Transforming Growth Factors,Xenopus laevis,Drosophila Proteins,Homeodomain Proteins,Insect Proteins,Mago protein, Drosophila,Magoh protein, mouse,Nuclear Proteins,RNA, Messenger,Recombinant Fusion Proteins,Trans-Activators,Transforming Growth Factor alpha,bicoid protein, Drosophila,gurken protein, Drosophila,Transforming Growth Factors,Kinesin
Howard Hughes Medical Institute, Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder 80309-0347, USA
Development
NIGMS 2T32-GM07135
0950-1991
120
True
9272960
