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The transmembrane molecule kekkon 1 acts ... a EGF receptor during oogenesis
The transmembrane molecule kekkon 1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis.
3
We have identified the Drosophila transmembrane molecule kekkon 1 (kek1) as an inhibitor of the epidermal growth factor receptor (EGFR) and demonstrate that it acts in a negative feedback loop to modulate the activity of the EGFR tyrosine kinase. During oogenesis, kek1 is expressed in response to the Gurken/EGFR signaling pathway, and loss of kek1 activity is associated with an increase in EGFR signaling. Consistent with our loss-of-function studies, we demonstrate that ectopic overexpression of kek1 mimics a loss of EGFR activity. We show that the extracellular and transmembrane domains of Kek1 can inhibit and physically associate with the EGFR, suggesting potential models for this inhibitory mechanism.
Ghiglione C, Carraway KL, Amundadottir LT, Boswell RE, Perrimon N, Duffy JB
Cell
1999-03-19 00:00
96
6
847-56
Animals,Binding Sites,Ca(2+)-Calmodulin Dependent Protein Kinase,Drosophila,Drosophila Proteins,Feedback,Gene Expression,Insect Proteins,MAP Kinase Kinase 1,Membrane Proteins,Mitogen-Activated Protein Kinase Kinases,Nerve Tissue Proteins,Oogenesis,Protein-Serine-Threonine Kinases,Protein-Tyrosine Kinases,Protein-Tyrosine-Phosphatase,Proto-Oncogene Proteins c-raf,Receptor, Epidermal Growth Factor,Signal Transduction,Transforming Growth Factor alpha,Transforming Growth Factors,ras Proteins,Drosophila Proteins,Insect Proteins,Membrane Proteins,Nerve Tissue Proteins,Transforming Growth Factor alpha,gurken protein, Drosophila,Transforming Growth Factors,MAP Kinase Kinase 1,Mitogen-Activated Protein Kinase Kinases,Protein-Tyrosine Kinases,Receptor, Epidermal Growth Factor,Ca(2+)-Calmodulin Dependent Protein Kinase,Protein-Serine-Threonine Kinases,Proto-Oncogene Proteins c-raf,Kek1 protein, Drosophila,Protein-Tyrosine-Phosphatase,ras Proteins
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell
NCI CA71702
0092-8674
S0092-8674(00)80594-2
116
True
10102272
