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Genetic analysis of Drosophila melanogas ... red for viability and fertility
Genetic analysis of Drosophila melanogaster polytene chromosome region 44D-45F: loci required for viability and fertility.
3
A genetic screen to identify mutations in genes in the 45A region on the right arm of chromosome 2 that are involved in oogenesis in Drosophila was undertaken. Several lethal but no female sterile mutations in the region had previously been identified in screens for P-element insertion or utilizing X rays or EMS as a mutagen. Here we report the identification of EMS-induced mutations in 21 essential loci in the 45D-45F region, including 13 previously unidentified loci. In addition, we isolated three mutant alleles of a newly identified locus required for fertility, sine prole. Mutations in sine prole disrupt spermatogenesis at or before individualization of spermatozoa and cause multiple defects in oogenesis, including inappropriate division of the germline cyst and arrest of oogenesis at stage 4.
Mohr SE, Boswell RE
Genetics
2002-04-01 00:00
160
4
1503-10
Animals,Chromosome Mapping,Drosophila Proteins,Drosophila melanogaster,Egg Proteins,Female,Fertility,Male,Mutation,Sequence Analysis, DNA,Drosophila Proteins,Egg Proteins,encore protein, Drosophila
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347, USA
Genetics
NIGMS 5T32-GM 07135, NIGMS GM-57989
0016-6731
95
True
11973305
