Tin Tin Su
Phone: (303) 735-3245
B.A., Mount Holyoke College, 1984
Ph.D., Carnegie Mellon University, 1991
Cell-cycle regulation; checkpoints; radiation biology; using Drosophila for cancer drug screening
Our goal is to understand how cells safe-guard their genetic information. We want to know how they do this during their normal course of life as well as when they become exposed to external insults like radiation that can damage DNA. Loss of genetic information can result in death and disease. By understanding how cells safe-guard their genetic information, we may help prevent or treat diseases that result from loss of genetic information such as cancer.
We use Drosophila melanogaster (fruit fly) in our studies because it is a good model for human biology (read more about this).
Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity.
Garcia, K, Stumpff, J, Duncan, T, and Su, TT Curr Biol, 19(19):1670-6. 2009
Why peer discussion improves student performance on in-class concept questions.
Smith, MK, Wood, WB, Adams, WK, Wieman, C, Knight, JK, Guild, N, and Su, TT Science, 323(5910):122-4. 2009
Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila.
Jaklevic, B, Uyetake, L, Wichmann, A, Bilak, A, English, CN, and Su, TT Dev Biol, 320(1):122-30. 2008
E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila.
Wichmann, A, Uyetake, L, and Su, TT Developmental Biology, 346(1):80-89. 2010
Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells.
Edwards, A, Gladstone, M, Yoon, P, Raben, D, Frederick, B, and Su, TT Dis Model Mech, 4(4):496-503. 2011